{"id":311,"date":"2023-09-25T11:30:18","date_gmt":"2023-09-25T11:30:18","guid":{"rendered":"https:\/\/research.iitgn.ac.in\/compbio\/?page_id=311"},"modified":"2026-02-23T11:20:15","modified_gmt":"2026-02-23T11:20:15","slug":"research","status":"publish","type":"page","link":"https:\/\/research.iitgn.ac.in\/compbio\/","title":{"rendered":"Research"},"content":{"rendered":"\n
\"\"<\/figure>
\n

DYNAMICS OF BIOMACROMOLECULES\u200b<\/strong><\/p>\n\n\n\n

    \n
  • Molecular dynamics simulations of clock proteins and lectins\u200b.<\/li>\n\n\n\n
  • Modeling intrinsically disordered regions\u200b.<\/li>\n\n\n\n
  • Understanding conformational changes in macromolecules\u200b.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n
    \n

    MATHEMATICAL MODELING<\/strong><\/p>\n\n\n\n

      \n
    • Modeling different gene network circuits using Ordinary Differential Equations (ODEs). <\/li>\n\n\n\n
    • Understanding plant circadian rhythms under  different physiological conditions.\u200b<\/li>\n<\/ul>\n<\/div>
      \"\"<\/figure><\/div>\n\n\n\n
      \"\"<\/figure>
      \n

      NETWORK BIOLOGY<\/strong><\/p>\n\n\n\n

        \n
      • Network biology approach to understand protein structures and function\u200b <\/li>\n\n\n\n
      • Reconstruction of gene regulatory networks in circadian skeletal-muscle transcription\u200b.<\/li>\n\n\n\n
      • Multilayer modeling of Network of Structure Networks.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n
        \n

        DRUG DISCOVERY\u200b<\/strong><\/p>\n\n\n\n

          \n
        • Structure based virtual screening of compounds\u200b.<\/li>\n\n\n\n
        • To explore the transient or cryptic novel binding pockets.\u200b<\/li>\n\n\n\n
        • To predict novel compounds that bind to core clock proteins.\u200b<\/li>\n\n\n\n
        • Studying the dynamics of protein – ligand complexes.<\/li>\n<\/ul>\n<\/div>
          \"\"<\/figure><\/div>\n\n\n\n
          \"\"<\/figure>
          \n

          INTEGRATIVE MODELING<\/strong><\/p>\n\n\n\n

            \n
          • Using computational methods to combine data from experiments like cryo EM, NMR, XRD, SAXS and XFEL.\u200b<\/li>\n\n\n\n
          •  To explore structure & dynamics of  circadian complexes.\u200b<\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-311","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Prithvinath Gollakota","author_link":"https:\/\/research.iitgn.ac.in\/compbio\/author\/prithvinath\/"},"uagb_comment_info":0,"uagb_excerpt":null,"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/pages\/311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/comments?post=311"}],"version-history":[{"count":3,"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/pages\/311\/revisions"}],"predecessor-version":[{"id":655,"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/pages\/311\/revisions\/655"}],"wp:attachment":[{"href":"https:\/\/research.iitgn.ac.in\/compbio\/wp-json\/wp\/v2\/media?parent=311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}